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However, subsequent ran-domized, placebo-controlled trials swung the pendu-lum the other direction. Painrelief, sedation and neuromuscular blockade areall important aspects of neonatal intensive care,yet many questions remain unanswered abouthow to optimise treatment with pharmacologi-cal agents

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The safety and efficacy of infliximab after failure of cyclosporine, or of cyclosporineafter infliximab, is uncertain. The absolute CD4 T cell numbers between respondingand non-responding patients were the same, but the percentage of CD8 T cells was higher inresponders. An elevated ratio ofperipheral airway resistance to central airwayresistance (and its contribution to total airwayresistance) in young children compared to adultswas originally proposed by Hogg et al.

Theability to predict novel events or new phenomena is the fourth characteristic of a soundtheory. None of the changes were signifi cantfor the thalamus.

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